发给老马备查:) I5 v6 x6 p ? \
滴水察海(69304838) 15:23:23; C% I) M% T, x6 s L6 y; G c4 a
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
0 m. ]# H0 a9 G$ Q0 S! G吉非替尼和S-1连用的依据
( h+ u: m" c) V: K5 J( U5 }$ sGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
! b( c" S# l. O4 O是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
# V9 ]. y, z" a$ l3 G这样是不是推理出,耐药后,可以用S-1和培美了?9 N# i& F* r% |7 `+ @
结论:+ ^; |4 W/ o# r8 t* D. p
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |