发给老马备查:2 G) ]' H: ^2 D& ~2 N8 U
滴水察海(69304838) 15:23:23 Q2 M* H& s9 I# P, l: X, }
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
0 q% R1 {) k- `& O吉非替尼和S-1连用的依据
, ^, y* U" O N' o6 l+ w" k$ VGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.) |- W' U. u3 J7 v
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达) K P$ v4 V+ O" I
这样是不是推理出,耐药后,可以用S-1和培美了?
y7 L5 A# N) g7 o5 `' F结论:
# H2 V+ E6 Y8 y) I( y如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |