发给老马备查:1 M7 D }; V; c" s9 y- k) Y, X6 T2 O- \
滴水察海(69304838) 15:23:231 ?/ h& m$ x9 b; Y$ z
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱+ K9 S" M, f. e. r s2 p' S
吉非替尼和S-1连用的依据0 z/ ?8 b. i! v3 ?
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
3 u; ?( _: Q6 N) j! O1 U5 u是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达# F8 `) u& B9 o5 s
这样是不是推理出,耐药后,可以用S-1和培美了?- b6 e% A( J0 T' _0 D
结论:* { z1 p% r# K Z9 m
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |